Bulking II: Classifications of Cellular Automata

This paper is the second part of a series of two papers dealing with bulking: a way to define quasi-order on cellular automata by comparing space-time diagrams up to rescaling. In the present paper, we introduce three notions of simulation between cellular automata and study the quasi-order structures induced by these simulation relations on the whole set of cellular automata. Various aspects of these quasi-orders are considered (induced equivalence relations, maximum elements, induced orders, etc) providing several formal tools allowing to classify cellular automata

GPS-derived interseismic coupling on the subduction and seismic hazards in the Atacama region, Chile

International audienceThe Atacama region (between 29°S and 25°S) is located in the North-Central area of Chile, a tectonically complex transition area between North and Central Chile. Deformation in Atacama is due mainly to elastic loading on the subduction interface but also to diffuse shortening in the Sierras Pampeanas, Argentina. The seismicity of the subduction is complex in this region: seismic swarms often occur, moderate (Mw ∼ 6) to large (Mw ∼ 7) earthquakes occur repeatedly and finally, megathrust earthquakes of magnitudes significantly larger than 8 occur once in a while, the last one being in 1922—almost a century ago. We use new GPS data we collected in the Atacama region between 2008 and 2012 to complete and densify existing data we acquired since 2004 in North-Central Chile. These new data allow to quantify the motion of the Andean sliver and assess the kinematic coupling on the subduction interface at these latitudes. We find that only 7 per cent of the whole convergence motion is taken up by an eastward rotation of the rigid sliver. A large part of the remaining 93 per cent (approximately 6 cm/yr) gives way to accumulation of elastic deformation in the upper plate, due to locking on the plate interface. This accumulation shows important along-strike and along-dip variations, interpreted in terms of variable coupling which we correlate with seismicity. We identify two areas of low coupling near the 'La Serena' (30°S) and 'Baranquilla' (27.5°S) bays. Both are correlated with the subduction of singular bathymetric features and seem to stop the propagation of large seismic ruptures. These zones are also seismic swarm prone areas, which seem to occur rather on their edges. These low coupling areas separate two seismic segments where coupling is high: the Atacama segment ( ∼100 km long between 29◦S and 28◦S) and the Cha ̃naral segment (∼200 km long between 27◦S and 25◦S). Should they rupture alone, these segments are sufficiently coupled and apparently since long enough, to produce Mw∼8 events. However, a collective failure of both segments could generate a megathrust earthquake of magnitude close to 8.5, similar to the 1819 and 1922 complex events, which produced important tsunamis. Such giant events may occur in the area once a century

Revisiting the North Chile seismic gap segmentation using GPS-derived interseismic coupling

International audienceNo major earthquake occurred in North Chile since the 1877 M w 8.6 subduction earthquake that produced a huge tsunami. However, geodetic measurements conducted over the last decade in this area show that the upper plate is actually deforming, which reveals some degree of locking on the subduction interface. This accumulation of elastic deformation is likely to be released in a future earthquake. Because of the long elapsed time since 1877 and the rapid accumulation of deformation (thought to be 6–7 cm/yr), many consider this area is a mature seismic gap where a major earthquake is due and seismic hazard is high. We present a new Global Positioning System (GPS) velocity field, acquired between 2008 and 2012, that describes in some detail the interseismic deformation between 18°S and 24°S. We invert for coupling distribution on the Nazca-South America subduction interface using elastic modelling. Our measurements require that, at these latitudes, 10 to 12 mm yr−1 (i.e. 15 per cent of the whole convergence rate) are accommodated by the clockwise rotation of an Andean block bounded to the East by the subandean fold-and-thrust belt. This reduces the accumulation rate on the subduction interface to 56 mm yr−1 in this area. Coupling variations on the subduction interface both along-strike and along-dip are described. We find that the North Chile seismic gap is segmented in at least two highly locked segments bounded by narrow areas of weak coupling. This coupling segmentation is consistent with our knowledge of the historical ruptures and of the instrumental seismicity of the region. Intersegment zones (Iquique, Mejillones) correlate with high background seismic rate and local tectonic complexities on the upper or downgoing plates. The rupture of either the Paranal or the Loa segment alone could easily produce a Mw 8.0–8.3 rupture, and we propose that the Loa segment (from 22.5◦S to 20.8◦S) may be the one that ruptured in 1877

Plum pudding random medium model of biological tissue toward remote microscopy from spectroscopic light scattering

Biological tissue has a complex structure and exhibits rich spectroscopic behavior. There is \emph{no} tissue model up to now able to account for the observed spectroscopy of tissue light scattering and its anisotropy. Here we present, \emph{for the first time}, a plum pudding random medium (PPRM) model for biological tissue which succinctly describes tissue as a superposition of distinctive scattering structures (plum) embedded inside a fractal continuous medium of background refractive index fluctuation (pudding). PPRM faithfully reproduces the wavelength dependence of tissue light scattering and attributes the "anomalous" trend in the anisotropy to the plum and the powerlaw dependence of the reduced scattering coefficient to the fractal scattering pudding. Most importantly, PPRM opens up a novel venue of quantifying the tissue architecture and microscopic structures on average from macroscopic probing of the bulk with scattered light alone without tissue excision. We demonstrate this potential by visualizing the fine microscopic structural alterations in breast tissue (adipose, glandular, fibrocystic, fibroadenoma, and ductal carcinoma) deduced from noncontact spectroscopic measurement

Electrophysiological evidence for an early processing of human voices

<p>Abstract</p> <p>Background</p> <p>Previous electrophysiological studies have identified a "voice specific response" (VSR) peaking around 320 ms after stimulus onset, a latency markedly longer than the 70 ms needed to discriminate living from non-living sound sources and the 150 ms to 200 ms needed for the processing of voice paralinguistic qualities. In the present study, we investigated whether an early electrophysiological difference between voice and non-voice stimuli could be observed.</p> <p>Results</p> <p>ERPs were recorded from 32 healthy volunteers who listened to 200 ms long stimuli from three sound categories - voices, bird songs and environmental sounds - whilst performing a pure-tone detection task. ERP analyses revealed voice/non-voice amplitude differences emerging as early as 164 ms post stimulus onset and peaking around 200 ms on fronto-temporal (positivity) and occipital (negativity) electrodes.</p> <p>Conclusion</p> <p>Our electrophysiological results suggest a rapid brain discrimination of sounds of voice, termed the "fronto-temporal positivity to voices" (FTPV), at latencies comparable to the well-known face-preferential N170.</p

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin–Siris syndrome

Purpose: Pathogenic variants in ARID1B are one of the most frequent causes of intellectual disability (ID) as determined by large-scale exome sequencing studies. Most studies published thus far describe clinically diagnosed Coffin–Siris patients (ARID1B-CSS) and it is unclear whether these data are representative for patients identified through sequencing of unbiased ID cohorts (ARID1B-ID). We therefore sought to determine genotypic and phenotypic differences between ARID1B-ID and ARID1B-CSS. In parallel, we investigated the effect of different methods of phenotype reporting. Methods: Clinicians entered clinical data in an extensive web-based survey. Results: 79 ARID1B-CSS and 64 ARID1B-ID patients were included. CSS-associated dysmorphic features, such as thick eyebrows, long eyelashes, thick alae nasi, long and/or broad philtrum, small nails and small or absent fifth distal phalanx and hypertrichosis, were observed significantly more often (p < 0.001) in ARID1B-CSS patients. No other significant differences were identified. Conclusion: There are only minor differences between ARID1B-ID and ARID1B-CSS patients. ARID1B-related disorders seem to consist of a spectrum, and patients should be managed similarly. We demonstrated that data collection methods without an explicit option to report the absence of a feature (such as most Human Phenotype Ontology-based methods) tended to underestimate gene-related features

Automates à galets : un état de l'art.

The purpose of this paper is to give an overview on pebble automata, which can be encountered in different domains, as figures (families) recognition, complexity theory and labyrinths theory . It gives definitions, examples and some basic theorems with their proofs.Ce rapport est un état de l'art sur les automates à galets que l'on rencontre dans divers domaines comme celui de la reconnaissance de (familles de) figures, théorie de la Complexité, mais aussi théorie des labyrinthes

Automates à galets : un état de l'art.

The purpose of this paper is to give an overview on pebble automata, which can be encountered in different domains, as figures (families) recognition, complexity theory and labyrinths theory . It gives definitions, examples and some basic theorems with their proofs.Ce rapport est un état de l'art sur les automates à galets que l'on rencontre dans divers domaines comme celui de la reconnaissance de (familles de) figures, théorie de la Complexité, mais aussi théorie des labyrinthes